Researchers have found a chemical in the body that when activated reduces obesity and metabolic diseases (in mice at the very least).
The chemical Beta-LGND2 needs to be activated by the estrogen receptor ER-Beta, which in turns white fat into brown fat cells. Brown fat increases metabolism and may facilitate weight loss. This was discovered by researchers at the University of Tennessee Health Science Center in Memphis, Tennessee and published in the journal FASEB.
“Although there is a general misperception that obesity is not a life-threatening condition, obesity is the underlying cause for several diseases that could result in mortality,” said Ramesh Narayanan, Ph.D., M.B.A., a researcher involved in the work from the Department of Medicine and Director of the Center for Cancer Drug Discovery. “Safe and effective treatment for obesity is highly needed, and targeting ER-β might be one of the strategies to safely combat obesity.”
“The notion that the fat in our bodies comes in two physiological forms has long been known, but here we have the intriguing prospect of a beneficial pharmacological switch.” said Thoru Pederson, Ph.D., Editor-in-Chief of The FASEB Journal.
The notion that the fat in our bodies comes in two physiological forms has long been known, but here we have the intriguing prospect of a beneficial pharmacological switch.
However a study published August 8th in Cell Reports found that there’s no such thing as “healthy obesity”. Healthy obesity was previously measured as how well the person suffering obesity could react to insulin which promotes the uptake of blood glucose into cells to be used for energy.
What was found however was that the tissue was near identical with abnormal changes in gene expression in response to insulin stimulation of both metabolically healthy or unhealthy people.
This new data means that this assumption may be wrong. Now no line for what marks “healthy obesity” exists.
But Beta-LGND2 could still help with weight loss none-the-less, and with one in three of us being overweight, further research into this field is a godsend.